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During Xenopus laevis embryogenesis, the most dorsal part of the embryo (dorsal blastomere) divides symmetrically while the two ventral blastomeres remain in the 2- and 4-cell stages. The initial asymmetric division in the epiblast is mediated by the inhibition of cell division in one cell by a graded adhesion between the epiblast and the extraembryonic endoderm in the future dorsal (more dorsal) part of the embryo. The present study shows that dorsally localized Wolffian body (Wb)-like cells and extraembryonic endoderm, which are believed to underlie this localized inhibition, provide the inhibitory signal that determines the right versus left embryonic axis in the 2-cell stage. The inhibitory signal acts first on the right blastomere and then on the left blastomere by inhibiting the formation of the anterior left versus posterior right mesoderm boundary at the 2-cell stage. The inhibitory signal must be released at the 4-cell stage to allow the formation of two ventral cell populations in the embryo.[The use of colloidal renin inhibitor compounds in the treatment of chronic occlusion of blood vessels].
Colloidal renin inhibitors are synthetic analogues of benzoyl-alanyl-alanyl-valine-lysine-leucine-arginine-arginine (Bzl-Ala-Ala-Val-Lys-Leu-Arg-Arg) bound to dextran. The inhibitors are the cheapest and most effective in vitro inhibitors that can be used in extracorporeal experiments. Bzl-Ala-Ala-Val-Lys-Leu-Arg-Arg can be used in blood circulation and thus influence the activity of renin, angiotensin II and the regulation of haemodynamics
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